Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.76 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.76 |
| ▸ | MTOR | P42345 | 12/20 | 0.67 |
| ▸ | PRKDC | P78527 | 2/20 | 0.61 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.61 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | PAK4 | O96013 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | FGR | P09769 | 1/20 | 0.61 |
| ▸ | FER | P16591 | 1/20 | 0.61 |
| ▸ | PRKCA | P17252 | 1/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.61 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13557987 | 0.91 | PIK3CA (0.81) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180645 | 0.90 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180642 | 0.90 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181071 | 0.89 | PIK3CA (0.84) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL13558058 | 0.88 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1180687 | 0.87 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL13557986 | 0.86 | PIK3CA (0.84) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL4440237 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL13558014 | 0.85 | PIK3CA (0.82) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL22674604 | 0.80 | PIK3CA (0.88) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2518074-A1 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2012-10-31 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |