Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212339 | 0.91 | CNR1 (0.47) | NPC1RAB9ATP53LMNAPOLB | |
| SCHEMBL14043554 | 0.80 | CNR1 (0.59) | NPC1RAB9ATP53LMNAPOLB | |
| SCHEMBL13808042 | 0.79 | CNR1 (0.60) | TP53LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL8204811 | 0.76 | TP53 (0.64) | NPC1RAB9ATP53LMNAPOLB | |
| SCHEMBL8212760 | 0.74 | CNR1 (0.52) | NPC1RAB9ATP53LMNAPOLB | |
| SCHEMBL8213517 | 0.72 | CNR1 (0.59) | NPC1RAB9ALMNAPOLBCNR1 | |
| SCHEMBL13807990 | 0.71 | TP53 (0.55) | TP53LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL13808007 | 0.71 | TP53 (0.67) | TP53LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL5064860 | 0.71 | CNR1 (0.57) | TP53LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL13808038 | 0.70 | TP53 (0.56) | TP53LMNAPOLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118141-A2 | USE OF CANNABINOID MODULATING COMPOUNDS IN COMBINATION WITH OTHER THERAPEUTIC COMPOUNDS FOR ADJUNCTIVE THERAPY | ACADIA PHARMACEUTICALS INC. (US) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008048648-A2 | CB1-MODULATING COMPOUNDS AND THEIR USE | ACADIA PHARMACEUTICALS INC. (US) | 2008-04-24 | — | — | WO | disclosed |