SCHEMBL8213149

SCHEMBL8213149

c1ccc2c(NCCCCNCCCNc3c4ccccc4nc4ccccc34)c3ccccc3nc2c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 5/20 0.70
RAD52 P43351 5/20 0.70
SLC2A1 P11166 4/20 0.64
RAB9A P51151 3/20 0.64
KMT2A Q03164 3/20 0.64
NPC1 O15118 2/20 0.64
APOBEC3A P31941 1/20 0.64
APOBEC3G Q9HC16 1/20 0.64
KDM4E B2RXH2 2/20 0.64
LMNA P02545 2/20 0.64
GLA P06280 2/20 0.64
GAA P10253 2/20 0.64
MITF O75030 1/20 0.64
ALDH1A1 P00352 1/20 0.64
TTR P02766 1/20 0.64
CACNA2D1 P54289 1/20 0.63
HRH3 Q9Y5N1 1/20 0.57
NPSR1 Q6W5P4 1/20 0.55
BCHE P06276 5/20 0.54
ACHE P22303 5/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5578493 0.93 POLB (0.79) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL7869214 0.93 POLB (0.79) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL13856923 0.91 POLB (0.77) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL6033155 0.91 POLB (0.77) POLBRAD52SLC2A1RAB9AKMT2A
Hydrochloric Acid SCHEMBL18334834 0.87 POLB (0.72) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL28396538 0.87 POLB (0.68) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL28888931 0.87 POLB (0.68) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL28396572 0.85 POLB (0.66) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL28396669 0.85 POLB (0.66) POLBRAD52SLC2A1RAB9AKMT2A
SCHEMBL28405740 0.85 POLB (0.66) POLBRAD52SLC2A1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11028121-B2 Multisignal labeling reagents and processes and uses therefor ENZO LIFE SCIENCES, INC. (US) 2021-06-08 US disclosed
US-20200270297-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR ENZO LIFE SCIENCE, INC. (US) 2020-08-27 US disclosed
US-10647740-B2 Multisignal labeling reagents and processes and uses therefor ENZO LIFE SCIENCE, INC. (US) 2020-05-12 US disclosed
US-10640529-B2 Multisignal labeling reagents and processes and uses therefor ENZO LIFE SCIENCES, INC. (US) 2020-05-05 US disclosed
US-20180127455-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR Enzo Life Science, Inc., c/o Enzo Biochem, Inc. (US) 2018-05-10 US disclosed
US-20180127456-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR Enzo Life Science, Inc., c/o Enzo Biochem, Inc. (US) 2018-05-10 US disclosed
US-9884889-B2 Multisignal labeling reagents and processes and uses therefor ENZO LIFE SCIENCES, INC. (US) 2018-02-06 US disclosed
US-20160025716-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR Enzo Life Science, Inc., c/o Enzo Biochem, Inc. (US) 2016-01-28 US disclosed
US-9156986-B2 Multisignal labeling reagents and processes and uses therefor ENZO LIFE SCIENCES, INC. (US) 2015-10-13 US disclosed
WO-2012128898-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR ENZO LIFE SCIENCES, INC. (US) 2012-09-27 WO disclosed
US-20110318788-A1 Multisignal labeling reagents and processes and uses therefor ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC. (US) 2011-12-29 US disclosed
US-6113946-A EUKARYOTIC CELL, POLYNUCLEOTIDE AND DENDRIMER POLYCATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-09-05 US disclosed
US-5990089-A INTRODUCING A POLYNUCLEOTIDE INTO A EUKARYOTIC CELL IN A LIVING ANIMAL COMPRISING CONTACTING THE CELL WITH A COMPOSITION COMPRISING A POLYNUCLEOTIDE AND A DENDRIMER POLYCATION COUPLED TO THE POLYNUCLEOTIDE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-11-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10647740-B2 Multisignal labeling reagents and processes and uses therefor PCNA, LIG4, LIG1 POLB 88/4885RAD52 304/4885SLC2A1 4573/4885
US-20110318788-A1 Multisignal labeling reagents and processes and uses therefor PCNA, LIG4, LIG1 POLB 88/4885RAD52 304/4885SLC2A1 4573/4885
US-10640529-B2 Multisignal labeling reagents and processes and uses therefor PCNA, LIG4, LIG1 POLB 88/4885RAD52 304/4885SLC2A1 4573/4885
US-20180127455-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR PCNA, LIG4, LIG1 POLB 88/4885RAD52 304/4885SLC2A1 4573/4885
US-20180127456-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR PCNA, LIG4, LIG1 POLB 88/4885RAD52 304/4885SLC2A1 4573/4885
US-11028121-B2 Multisignal labeling reagents and processes and uses therefor PCNA, LIG4, LIG1 POLB 88/4885RAD52 304/4885SLC2A1 4573/4885
US-20200270297-A1 MULTISIGNAL LABELING REAGENTS AND PROCESSES AND USES THEREFOR PCNA, LIG4, LIG1 POLB 88/4885RAD52 304/4885SLC2A1 4573/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.