Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | RAB9A | P51151 | 10/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13510677 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL13509036 | 0.79 | KDM4E (0.42) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8205966 | 0.77 | KMT2A (0.48) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8013007 | 0.70 | TDP1 (0.42) | KDM4EALDH1A1MAPTGAAL3MBTL1 | |
| SCHEMBL11993125 | 0.70 | MAPT (0.44) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8215286 | 0.68 | KMT2A (0.41) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10435152 | 0.68 | KDM4E (0.49) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| (Z)-1,2-Diphenylethene SCHEMBL28557293 | 0.67 | MAOB (0.61) | ALDH1A1LMNAMAPK1KMT2ARELA | |
| (Z)-1,2-Diphenylethene SCHEMBL1892609 | 0.67 | MAOB (0.61) | ALDH1A1LMNAMAPK1KMT2ARELA | |
| (Z)-1,2-Diphenylethene SCHEMBL1892612 | 0.67 | MAOB (0.61) | ALDH1A1LMNAMAPK1KMT2ARELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662779-B2 | Triazolyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090047248-A1 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-02-19 | — | — | US | disclosed |
| WO-2008021960-A2 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047248-A1 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, CTSC | KDM4E 1545/4885ALDH1A1 1237/4885RAB9A 3387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.