Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588100 | 0.88 | PIK3CA (0.54) | HRH4PIK3CAMTORATRPOLB | |
| SCHEMBL3592743 | 0.82 | PIK3CA (0.54) | PIK3CAATRPIK3R1 | |
| SCHEMBL8219150 | 0.82 | HRH4 (0.44) | HRH4PIK3CAMTORATRPOLB | |
| SCHEMBL3404233 | 0.80 | HRH4 (0.55) | HRH4PIK3CAATRPOLBKMT2A | |
| SCHEMBL8217236 | 0.79 | PIK3CA (0.44) | HRH4PIK3CAMTORATRPOLB | |
| SCHEMBL856718 | 0.75 | MAPT (0.61) | HRH4PIK3CAPOLBKMT2AMAPT | |
| SCHEMBL2489923 | 0.73 | POLB (0.55) | PIK3CAMTORATRPOLBKMT2A | |
| SCHEMBL3592915 | 0.72 | PIK3CA (0.51) | PIK3CAMTORATRPIK3R1 | |
| SCHEMBL2531188 | 0.71 | KMT2A (0.68) | HRH4KMT2AMAPTCYP1A2CYP2D6 | |
| SCHEMBL1271807 | 0.71 | MTOR (0.65) | PIK3CAMTORATRPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |