SCHEMBL856718

SCHEMBL856718

Clc1nc(N2CCOCC2)cc(N2CCOCC2)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.61
CYP1A2 P05177 1/20 0.61
CYP2D6 P10635 1/20 0.61
HTT P42858 1/20 0.56
KMT2A Q03164 4/20 0.56
CRHBP P24387 1/20 0.51
CRHR2 Q13324 1/20 0.51
MEN1 O00255 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
POLB P06746 1/20 0.49
NPSR1 Q6W5P4 2/20 0.47
TSHR P16473 1/20 0.47
MAPK1 P28482 1/20 0.47
HSD17B10 Q99714 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
HRH4 Q9H3N8 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29762330 0.90 MAPT (0.70) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL856815 0.90 MAPT (0.70) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL20267260 0.87 MAPT (0.61) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL30068134 0.87 MAPT (0.61) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL2531188 0.87 KMT2A (0.68) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL3188213 0.87 MAPT (0.53) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL18595294 0.87 MAPT (0.53) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL2493395 0.87 CYP1A2 (0.49) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL2476330 0.85 CYP1A2 (0.48) MAPTCYP1A2CYP2D6HTTKMT2A
SCHEMBL17859942 0.84 CYP1A2 (0.54) MAPTCYP1A2CYP2D6HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12497407-B2 Treatment of skin disorders TORQUR AG (CH) 2025-12-16 US disclosed
US-20240382496-A1 TREATMENT OF SKIN LESIONS TORQUR AG (CH) 2024-11-21 US disclosed
US-20240343718-A1 TREATMENT OF NEUROLOGICAL DISORDERS TORQUR AG (CH) 2024-10-17 US disclosed
US-11918586-B2 Treatment of skin lesions TORQUR AG (CH) 2024-03-05 US disclosed
US-11878972-B2 Treatment of neurological disorders TORQUR AG (CH) 2024-01-23 US disclosed
CN-109414415-B Treatment of skin lesions 拓客股份有限公司 2023-05-02 CN disclosed
CN-109475560-B Treatment of neurological disorders 巴塞尔大学 2023-05-02 CN disclosed
US-20230014057-A1 TREATMENT OF SKIN DISORDERS TORQUR AG (CH) 2023-01-19 US disclosed
US-20230014057-A1 TREATMENT OF SKIN DISORDERS TORQUR AG (CH) 2023-01-19 US disclosed
US-11414426-B2 Treatment of skin disorders TORQUR AG (CH) 2022-08-16 US disclosed
CN-101711241-A PI 3-kinase inhibitors and methods of their use NOVARTIS VACCINES & DIAGNOSTIC 2010-05-19 CN disclosed
US-20100048547-A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2010-02-25 US disclosed
US-20100048547-A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2010-02-25 US disclosed
US-20100048547-A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2010-02-25 US disclosed
EP-2118087-A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE Novartis Ag (CH) 2009-11-18 EP disclosed
EP-1984350-A1 PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS Novartis AG (CH) 2008-10-29 EP disclosed
WO-2008098058-A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2008-08-14 WO disclosed
WO-2008098058-A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2008-08-14 WO disclosed
WO-2007084786-A1 PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS NOVARTIS AG (CH) 2007-07-26 WO disclosed
WO-2007084786-A1 PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS NOVARTIS AG (CH) 2007-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240382496-A1 TREATMENT OF SKIN LESIONS C1R, C3AR1, CXCR3 MAPT 2395/4885CYP1A2 303/4885CYP2D6 348/4885
US-20240343718-A1 TREATMENT OF NEUROLOGICAL DISORDERS CHRM2, CHRM1, C1R MAPT 261/4885CYP1A2 136/4885CYP2D6 146/4885
US-20100048547-A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE PI4KA, PI4KB, PI4K2A MAPT 3354/4885CYP1A2 4501/4885CYP2D6 4810/4885
US-11878972-B2 Treatment of neurological disorders CHRM1, CHRM2, C1R MAPT 161/4885CYP1A2 124/4885CYP2D6 65/4885
US-12497407-B2 Treatment of skin disorders RXFP3, CCR3, CBR3 MAPT 2061/4885CYP1A2 405/4885CYP2D6 638/4885
US-20230014057-A1 TREATMENT OF SKIN DISORDERS RXFP3, CCR3, CBR3 MAPT 2061/4885CYP1A2 405/4885CYP2D6 638/4885
US-11918586-B2 Treatment of skin lesions C1R, C3AR1, CXCR3 MAPT 2395/4885CYP1A2 303/4885CYP2D6 348/4885
US-11414426-B2 Treatment of skin disorders RXFP3, CBR3, CXCR3 MAPT 2626/4885CYP1A2 352/4885CYP2D6 512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.