Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.51 |
| ▸ | MTOR | P42345 | 4/20 | 0.51 |
| ▸ | ATM | Q13315 | 11/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222644 | 0.93 | PIK3CA (0.51) | PIK3CAMTORATMKDRPIK3CD | |
| SCHEMBL8212562 | 0.89 | PIK3CA (0.53) | PIK3CAMTORATMKDRPIK3CD | |
| SCHEMBL8220891 | 0.87 | PIK3CA (0.64) | PIK3CAMTORATMKDRPIK3CD | |
| SCHEMBL8098329 | 0.85 | PIK3CA (0.55) | PIK3CAMTORATMKDRPIK3CD | |
| SCHEMBL8211441 | 0.84 | PIK3CA (0.54) | PIK3CAMTORATMKDRPIK3CD | |
| SCHEMBL8214019 | 0.83 | ATM (0.45) | PIK3CAMTORATMPIK3CDPIK3CG | |
| SCHEMBL8211601 | 0.83 | PIK3CA (0.48) | PIK3CAMTORKDRPIK3CD | |
| SCHEMBL11925970 | 0.82 | PIK3CA (0.50) | PIK3CAMTORATMKDRPIK3CD | |
| SCHEMBL8214580 | 0.82 | PIK3CA (0.57) | PIK3CAMTORATMPIK3CDPIK3CG | |
| SCHEMBL8204775 | 0.82 | PIK3CA (0.49) | PIK3CAMTORATMKDRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |