Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 14/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217617 | 0.90 | PIK3CA (0.41) | PIK3CAMTORPIK3CD | |
| SCHEMBL8215180 | 0.89 | NAMPT (0.46) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8205332 | 0.88 | PIK3CD (0.48) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8214032 | 0.88 | ATM (0.45) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8212594 | 0.87 | PIK3CA (0.49) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8205334 | 0.85 | PIK3CA (0.41) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8215294 | 0.85 | NAMPT (0.42) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8214596 | 0.83 | PIK3CA (0.51) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL11925811 | 0.83 | KIF11 (0.44) | PIK3CAMTORPIK3CD | |
| SCHEMBL11925440 | 0.83 | CA2 (0.42) | PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |