Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 10/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3068774 | 0.88 | GRM2 (0.47) | GRM2HRH3MLNR | |
| SCHEMBL13178889 | 0.80 | GRM2 (0.42) | GRM2MLNR | |
| SCHEMBL3068599 | 0.74 | GRM2 (0.49) | GRM2MLNRCYP3A4BACE1 | |
| SCHEMBL3076480 | 0.73 | HRH3 (0.51) | GRM2HRH3 | |
| SCHEMBL3068893 | 0.71 | GRM2 (0.44) | GRM2 | |
| SCHEMBL3077038 | 0.70 | AOC3 (0.42) | GRM2HRH3 | |
| SCHEMBL3067246 | 0.69 | ITGB1 (0.43) | GRM2HRH3BACE1 | |
| SCHEMBL3077066 | 0.68 | AOC3 (0.42) | GRM2HRH3 | |
| SCHEMBL3081725 | 0.68 | GRM2 (0.47) | GRM2HRH3BACE1 | |
| SCHEMBL8202227 | 0.68 | GRM2 (0.39) | GRM2MLNRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032191-A2 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (US) | 2008-03-20 | — | — | WO | disclosed |