Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16730520 | 1.00 | TSHR (0.64) | TSHRLMNAALDH1A1EPHX2PAOX | |
| SCHEMBL2586098 | 1.00 | TSHR (0.64) | TSHRLMNAALDH1A1EPHX2PAOX | |
| SCHEMBL20283628 | 1.00 | TSHR (0.64) | TSHRLMNAALDH1A1EPHX2PAOX | |
| Hydrochloric Acid SCHEMBL2579652 | 0.98 | TSHR (0.61) | TSHRLMNAALDH1A1EPHX2PAOX | |
| Hydrochloric Acid SCHEMBL2583424 | 0.98 | TSHR (0.61) | TSHRLMNAALDH1A1EPHX2PAOX | |
| SCHEMBL23132220 | 0.92 | TSHR (0.54) | TSHRLMNAALDH1A1EPHX2PAOX | |
| SCHEMBL132401 | 0.92 | TSHR (0.54) | TSHRLMNAALDH1A1EPHX2PAOX | |
| SCHEMBL13903720 | 0.92 | CA12 (0.59) | TSHRLMNAALDH1A1EPHX2CA12 | |
| SCHEMBL13903715 | 0.92 | CA12 (0.59) | TSHRLMNAALDH1A1EPHX2CA12 | |
| SCHEMBL18641686 | 0.92 | TSHR (0.54) | TSHRLMNAALDH1A1EPHX2PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794788-A4 | HEPATIC-DIRECTED COMPOUNDS AND REAGENTS FOR PREPARATION THEREOF | NEORX CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| EP-0794788-A1 | HEPATIC-DIRECTED COMPOUNDS AND REAGENTS FOR PREPARATION THEREOF | NEORX CORPORATION (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996017613-A1 | HEPATIC-DIRECTED COMPOUNDS AND REAGENTS FOR PREPARATION THEREOF | NEORX CORPORATION (US) | 1996-06-13 | — | — | WO | disclosed |