SCHEMBL8215010

SCHEMBL8215010

CCCC1CCC(c2ccc(-c3ccc(C4CCC(CCCOC)CC4)cc3F)cc2)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C9 P11712 3/20 0.41
CYP3A4 P08684 3/20 0.39
MEN1 O00255 1/20 0.39
MAPK1 P28482 1/20 0.39
KMT2A Q03164 1/20 0.39
APP P05067 2/20 0.37
FASN P49327 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
ESR2 Q92731 2/20 0.35
S1PR1 P21453 3/20 0.33
SGPL1 O95470 2/20 0.32
FFAR4 Q5NUL3 1/20 0.32
RORC P51449 1/20 0.32
DGAT1 O75907 1/20 0.31
SOAT1 P35610 1/20 0.31
S1PR3 Q99500 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8208461 0.93 ALDH1A1 (0.42) ALDH1A1LMNAMAPTCYP2C9MEN1
SCHEMBL8215094 0.91 ALDH1A1 (0.38) ALDH1A1LMNAMAPTCYP2C9CYP3A4
SCHEMBL15581273 0.90 CYP2C9 (0.38) CYP2C9CYP3A4APPFASNCYP2D6
SCHEMBL8216095 0.90 ALDH1A1 (0.38) ALDH1A1LMNAMAPTCYP2C9CYP3A4
SCHEMBL16258052 0.89 CYP2C9 (0.45) ALDH1A1LMNAMAPTCYP2C9CYP3A4
SCHEMBL17897885 0.89 CYP2C9 (0.45) ALDH1A1LMNAMAPTCYP2C9CYP3A4
SCHEMBL15581319 0.89 ALDH1A1 (0.37) ALDH1A1LMNAMAPTCYP2C9CYP3A4
SCHEMBL165846 0.89 CYP2C9 (0.49) ALDH1A1LMNAMAPTCYP2C9CYP3A4
SCHEMBL19789502 0.89 CYP2C9 (0.49) ALDH1A1LMNAMAPTCYP2C9CYP3A4
SCHEMBL165845 0.89 CYP2C9 (0.49) ALDH1A1LMNAMAPTCYP2C9CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117361-A FOUR RING COMPOUND HAVING AN ALKYL GROUP SUBSTITUTED WITH ONE OR MORE ETHERS, AND A HALOGEN ATOM SUBSTITUTED BENZENE RING; BROAD TEMPERATURE RANGE OF NEMATIC PHASE, HIGHER MISCIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS, AND CHEMICAL STABILITY CHISSO CORP. (JP) 2000-09-12 US disclosed
EP-0891961-A1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED 1,4-PHENYLENE SKELETONS, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORPORATION (JP) 1999-01-20 EP disclosed