Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL2939929 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL1033046 | 1.00 | — | — | |
| Benzene SCHEMBL28428218 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL9860731 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL5898844 | 1.00 | — | — | |
| Benzene SCHEMBL9860727 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL9860060 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL5320320 | 1.00 | — | — | |
| Benzene SCHEMBL2939930 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL5320317 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104131461-B | A kind of composition and method of making the same for field of textiles and purposes | GUANGDONG NIKEER CLOTHES CO., LTD. (CN) | 2016-03-09 | — | — | CN | claimed |
| CN-104131461-A | Composition used in textile field and preparation method and use thereof | YIN LEI | 2014-11-05 | — | — | CN | claimed |
| US-5384232-A | Process for rapid access development of silver halide films using pyridinium as development accelerators | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-01-24 | — | — | US | claimed |
| EP-3600656-B1 | UNSYMMETRICAL SALTS, CCC-NHC PINCER METAL COMPLEXES, AND METHODS OF MAKING THE SAME | UNIV MISSISSIPPI STATE (US) | 2025-01-15 | — | — | EP | disclosed |
| CN-116324060-B | Composite fiber and fiber structure comprising same | 可乐丽贸易株式会社 | 2024-05-14 | — | — | CN | disclosed |
| CN-112839922-B | Hydrophilic and in particular water-soluble DBOV derivatives | 马克斯·普朗克索赔科学公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117580824-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-116324060-A | Composite fiber and fiber structure comprising same | 可乐丽贸易株式会社 | 2023-06-23 | — | — | CN | disclosed |
| US-11618745-B2 | Unsymmeirical salts, CCC-NHC pincer metal complexes, and methods of making the same | MISSISSIPPI STATE UNIVERSITY (US) | 2023-04-04 | — | — | US | disclosed |
| CN-110358106-A | A kind of anion frame metal-organic framework material and its preparation method and application of pair of nitro-aromatic explosive sensing | 湖北师范大学 | 2019-10-22 | — | — | CN | disclosed |
| CN-104115236-B | Composition and the conductor formed by it | 道康宁公司 | 2017-12-19 | — | — | CN | disclosed |
| CN-104115236-A | COMPOSITION AND CONDUCTOR FORMED THEREFROM | DOW CORNING | 2014-10-22 | — | — | CN | disclosed |
| CN-103642042-A | Synthetic method of polyphenylene sulfide | UNIV SHANGHAI | 2014-03-19 | — | — | CN | disclosed |
| CN-102909079-A | Methyl aromatics oxidation catalyst system | CHINA PETROLEUM & CHEMICAL | 2013-02-06 | — | — | CN | disclosed |
| CN-101497566-A | Preparation of 2,5-bis(2,2,2-trifluoro ethoxy) benzene carbonic acid | Taicang Pharmaceutical Factory (CN) | 2009-08-05 | — | — | CN | disclosed |
| CN-1258325-A | Fibres made from long chain branched syndiotactic vinyl aromatic polymers | DOW CHEMICAL CO (US) | 2000-06-28 | — | — | CN | disclosed |
| WO-1998021521-A9 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS AND METHODS OF USE | CALIFORNIA INST OF TECHN (US) | 2000-03-02 | — | — | WO | disclosed |
| US-4548686-A | BROMINE PGOTOCATALYST | THE DOW CHEMICAL COMPANY (US) | 1985-10-22 | — | — | US | disclosed |
| WO-1984000358-A1 | SELECTIVE CATALYTIC PHOTOCHLORINATION OF 1,1-DICHLOROETHANE | DOW CHEMICAL CO (US) | 1984-02-02 | — | — | WO | disclosed |
| EP-0096404-A1 | Selective catalytic photochlorination of 1,1-dichloroethane | THE DOW CHEMICAL COMPANY (US) | 1983-12-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11618745-B2 | Unsymmeirical salts, CCC-NHC pincer metal complexes, and methods of making the same | NDC1, INO80C, HLCS | TSHR 4507/4885TP53 365/4885ALDH1A1 3911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.