Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.49 |
| ▸ | NAMPT | P43490 | 9/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11925415 | 0.90 | MAPK1 (0.45) | PIK3CDPIK3CANAMPTTSHR | |
| SCHEMBL8222567 | 0.86 | MAPK1 (0.40) | PIK3CDPIK3CANAMPTTSHR | |
| SCHEMBL8219056 | 0.85 | NAMPT (0.54) | PIK3CDPIK3CANAMPT | |
| SCHEMBL8213351 | 0.85 | TSHR (0.46) | PIK3CANAMPTTSHR | |
| SCHEMBL11926829 | 0.85 | PIK3CA (0.52) | PIK3CDPIK3CANAMPTTSHR | |
| SCHEMBL8215080 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CANAMPT | |
| SCHEMBL8219557 | 0.84 | NAMPT (0.56) | NAMPT | |
| SCHEMBL8214526 | 0.83 | PIK3CD (0.61) | PIK3CDPIK3CA | |
| SCHEMBL8097088 | 0.82 | TSHR (0.47) | PIK3CDPIK3CANAMPTTSHR | |
| SCHEMBL8216529 | 0.81 | PIK3CD (0.53) | PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |