Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 7/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091693 | 0.86 | MTOR (0.40) | PIK3CDPIK3CAMAPK1AURKB | |
| SCHEMBL8089874 | 0.85 | PIK3CD (0.45) | PIK3CDPIK3CA | |
| SCHEMBL11926829 | 0.85 | PIK3CA (0.52) | TSHRNAMPTPIK3CDPIK3CAMAPK1 | |
| SCHEMBL8096057 | 0.83 | MTOR (0.43) | PIK3CDPIK3CA | |
| SCHEMBL8083835 | 0.83 | MTOR (0.39) | PIK3CDPIK3CAMAPK1AURKB | |
| SCHEMBL8095579 | 0.83 | PIK3CD (0.44) | PIK3CDPIK3CA | |
| SCHEMBL8091538 | 0.83 | PIK3CD (0.43) | PIK3CDPIK3CA | |
| SCHEMBL8097227 | 0.83 | PIK3CD (0.43) | NAMPTPIK3CDPIK3CA | |
| SCHEMBL8215115 | 0.82 | PIK3CD (0.49) | TSHRNAMPTPIK3CDPIK3CA | |
| SCHEMBL8088795 | 0.82 | CNR1 (0.47) | NAMPTPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |