Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glutathione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.92 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.92 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.65 |
| ▸ | NOD1 | Q9Y239 | 7/20 | 0.46 |
| ▸ | FNTA | P49354 | 2/20 | 0.42 |
| ▸ | FNTB | P49356 | 2/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutathione SCHEMBL8215201 | 1.00 | PTGS1 (0.92) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL20298529 | 0.97 | PTGS1 (0.92) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL20298530 | 0.97 | PTGS1 (0.92) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL28212822 | 0.96 | PTGS1 (0.90) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL3790499 | 0.96 | PTGS1 (0.95) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL3790504 | 0.96 | PTGS1 (0.95) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL5167025 | 0.96 | PTGS1 (1.00) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL15701576 | 0.96 | PTGS1 (1.00) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL14364095 | 0.96 | PTGS1 (1.00) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione SCHEMBL1105665 | 0.96 | PTGS1 (1.00) | PTGS1GSTK1GLO1NOD1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6146616-A | A PLANT EXTRACTS FROM LUPINE OIL FOR IMPROVING THE SKIN APPEARANCE OF AN INDIVIDUAL; USE IN COSMETICS, PHARMACEUTICS AND AS FOOD ADDITIVE | LABORATORIES PHARMASCIENCE (FR) | 2000-11-14 | — | — | US | disclosed |