Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27489980 | 0.90 | TDP1 (0.42) | TDP1HTTPOLBKDM4ECTDSP1 | |
| Bromide SCHEMBL27462679 | 0.89 | TDP1 (0.41) | TDP1HTTPOLBKDM4ECTDSP1 | |
| SCHEMBL77335 | 0.84 | POLB (0.46) | TDP1HTTPOLBMEN1KMT2A | |
| SCHEMBL22116212 | 0.83 | TDP1 (0.45) | TDP1HTTPOLBKDM4ECTDSP1 | |
| SCHEMBL8214283 | 0.81 | ALDH1A1 (0.49) | TDP1HTTPOLBKDM4ECTDSP1 | |
| SCHEMBL11794035 | 0.81 | POLB (0.47) | TDP1HTTPOLBMEN1KMT2A | |
| SCHEMBL6707228 | 0.80 | TDP1 (0.62) | TDP1HTTPOLBKDM4ECTDSP1 | |
| SCHEMBL8211831 | 0.77 | TDP1 (0.59) | TDP1HTTPOLBKDM4ECTDSP1 | |
| SCHEMBL31052626 | 0.77 | TDP1 (0.45) | TDP1HTTPOLBKDM4ECTDSP1 | |
| SCHEMBL28207495 | 0.76 | IDO1 (0.45) | TDP1HTTPOLBKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110952-A | PREVENTING OR TREATING NASAL CONGESTION, OTITIS MEDIA AND SINUSITIS WITHOUT UNDESIRED SIDE EFFECTS, ALSO ASTHMA, PAIN, MIGRAINE, SUBSTANCE ABUSE AND ADDICTION, GASTROINTESTINAL DISORDER, ULCER, STOMACH HYPERACIDITY | THE PROCTER & GAMBLE COMPANY (US) | 2000-08-29 | — | — | US | disclosed |
| CN-1242015-A | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 2000-01-19 | — | — | CN | disclosed |
| EP-0944622-A1 | 2-IMIDAZOLINYLAMINOBENZOXAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023611-A1 | 2-IMIDAZOLINYLAMINOBENZOXAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |