Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.55 |
| ▸ | MMP1 | P03956 | 4/20 | 0.55 |
| ▸ | MMP3 | P08254 | 4/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | CETP | P11597 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209053 | 1.00 | MMP2 (0.55) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8221230 | 1.00 | MMP2 (0.55) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8216244 | 1.00 | MMP2 (0.55) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8221233 | 1.00 | MMP2 (0.55) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8216769 | 1.00 | MMP2 (0.55) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8216771 | 1.00 | MMP2 (0.55) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8209054 | 1.00 | MMP2 (0.55) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8209047 | 0.99 | MMP2 (0.53) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL8209048 | 0.99 | MMP2 (0.53) | MMP2MMP1MMP3MMP9MMP12 | |
| SCHEMBL19024799 | 0.91 | CETP (0.54) | CETPALDH1A1CYP3A4TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621270-B1 | Piperazine derivatives as collagenase inhibitors | SANKYO CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-5643908-A | ANGIOGENESIS INHIBITOR, ANTITUMOR | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0621270-A1 | COLLAGENASE INHIBITOR | SANKYO COMPANY LIMITED (JP) | 1994-10-26 | — | — | EP | disclosed |