Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010478 | 0.89 | GRM5 (0.58) | GRM5ALDH1A1POLBESR2ESR1 | |
| SCHEMBL1010202 | 0.89 | GRM5 (0.49) | GRM5BCL2BADALDH1A1POLB | |
| SCHEMBL13719671 | 0.85 | BCL2 (0.41) | BCL2BADALDH1A1POLBMAPT | |
| SCHEMBL8212864 | 0.81 | F11 (0.38) | GRM5ALDH1A1POLBESR2ESR1 | |
| SCHEMBL3816821 | 0.78 | BCL2 (0.41) | GRM5BCL2BADALDH1A1POLB | |
| SCHEMBL3820233 | 0.78 | MAPT (0.47) | BCL2BADALDH1A1POLBMAPT | |
| SCHEMBL1008827 | 0.74 | GRM5 (0.64) | GRM5ALDH1A1POLBESR2ESR1 | |
| SCHEMBL1009560 | 0.73 | GRM5 (0.53) | GRM5ALDH1A1POLBESR2ESR1 | |
| SCHEMBL6786075 | 0.72 | NOTUM (0.56) | ALDH1A1LMNA | |
| SCHEMBL8216502 | 0.72 | GRM5 (0.46) | GRM5BCL2BADALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015269-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | disclosed |