Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6ST | P40189 | 5/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 5/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8216419 | 1.00 | IL6ST (0.51) | IL6STNAAAACESTAT3FAAH | |
| SCHEMBL8220863 | 1.00 | IL6ST (0.51) | IL6STNAAAACESTAT3FAAH | |
| SCHEMBL7277673 | 0.90 | IL6ST (0.52) | IL6STNAAASTAT3IDH1 | |
| SCHEMBL8554613 | 0.86 | FAAH (0.40) | IL6STNAAAACEFAAHKLK7 | |
| SCHEMBL8554605 | 0.86 | FAAH (0.40) | IL6STNAAAACEFAAHKLK7 | |
| SCHEMBL8554608 | 0.86 | FAAH (0.40) | IL6STNAAAACEFAAHKLK7 | |
| SCHEMBL8218743 | 0.83 | IL6ST (0.52) | IL6STSTAT3 | |
| SCHEMBL6159291 | 0.83 | IL6ST (0.52) | IL6STSTAT3 | |
| SCHEMBL8218741 | 0.83 | IL6ST (0.52) | IL6STSTAT3 | |
| SCHEMBL6159290 | 0.83 | IL6ST (0.52) | IL6STSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621270-B1 | Piperazine derivatives as collagenase inhibitors | SANKYO CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-5643908-A | ANGIOGENESIS INHIBITOR, ANTITUMOR | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0621270-A1 | COLLAGENASE INHIBITOR | SANKYO COMPANY LIMITED (JP) | 1994-10-26 | — | — | EP | disclosed |