Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 12/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224650 | 0.93 | SMO (0.82) | SMOABCB1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8214331 | 0.93 | SMO (0.78) | SMOCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8222790 | 0.90 | SMO (0.70) | SMOABCB1MAPK14 | |
| SCHEMBL8221703 | 0.86 | SMO (0.68) | SMOCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8219897 | 0.85 | SMO (0.68) | SMOMAPK14CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL16250299 | 0.84 | SMO (0.52) | SMOABCB1 | |
| SCHEMBL12129968 | 0.83 | SMO (1.00) | SMOABCB1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12129951 | 0.83 | SMO (0.89) | SMOCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8225752 | 0.82 | SMO (0.82) | SMOABCB1MAPK14 | |
| SCHEMBL8296454 | 0.82 | SMO (0.72) | SMOMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889678-B2 | Acyl guanidine derivatives modulating the hedgehog protein signaling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-11-18 | — | — | US | claimed |
| EP-2456754-B1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | UNIV STRASBOURG (FR) | 2014-02-26 | — | — | EP | claimed |
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | claimed |
| EP-2456754-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | Universite De Strasbourg (FR) | 2012-05-30 | — | — | EP | claimed |
| WO-2011010013-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-01-27 | — | — | WO | claimed |
| US-8889678-B2 | Acyl guanidine derivatives modulating the hedgehog protein signaling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-11-18 | — | — | US | disclosed |
| US-8889678-B2 | Acyl guanidine derivatives modulating the hedgehog protein signaling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-11-18 | — | — | US | disclosed |
| US-8889678-B2 | Acyl guanidine derivatives modulating the hedgehog protein signaling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-11-18 | — | — | US | disclosed |
| EP-2456754-B1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | UNIV STRASBOURG (FR) | 2014-02-26 | — | — | EP | disclosed |
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | disclosed |
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | disclosed |
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | disclosed |
| EP-2456754-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | Universite De Strasbourg (FR) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011010013-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011010013-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | SHH, GLI1, SMO | SMO 3/4885ABCB1 3465/4885MAPK14 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.