Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 11/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225752 | 0.93 | SMO (0.82) | SMOMAPK14ABCB1 | |
| SCHEMBL8296454 | 0.92 | SMO (0.72) | SMOMAPK14MEN1ALDH1A1KMT2A | |
| SCHEMBL8216455 | 0.90 | SMO (0.71) | SMOMAPK14ABCB1 | |
| SCHEMBL15492187 | 0.89 | SMO (0.76) | SMOMAPK14ABCB1 | |
| SCHEMBL14809743 | 0.89 | SMO (0.70) | SMOMAPK14MEN1KMT2A | |
| SCHEMBL8223132 | 0.89 | SMO (0.79) | SMOMAPK14ABCB1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15938685 | 0.88 | SMO (0.69) | SMOMAPK14MEN1KMT2A | |
| SCHEMBL11911340 | 0.86 | SMO (0.71) | SMOMAPK14ABCB1ALDH1A1 | |
| SCHEMBL15944741 | 0.85 | SMO (0.68) | SMOMAPK14MEN1KMT2A | |
| SCHEMBL14809786 | 0.84 | SMO (0.67) | SMOMAPK14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889678-B2 | Acyl guanidine derivatives modulating the hedgehog protein signaling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-11-18 | — | — | US | claimed |
| EP-2456754-B1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | UNIV STRASBOURG (FR) | 2014-02-26 | — | — | EP | claimed |
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | claimed |
| EP-2456754-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | Universite De Strasbourg (FR) | 2012-05-30 | — | — | EP | claimed |
| WO-2011010013-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-01-27 | — | — | WO | claimed |
| US-8889678-B2 | Acyl guanidine derivatives modulating the hedgehog protein signaling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-11-18 | — | — | US | disclosed |
| US-8889678-B2 | Acyl guanidine derivatives modulating the hedgehog protein signaling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-11-18 | — | — | US | disclosed |
| EP-2456754-B1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | UNIV STRASBOURG (FR) | 2014-02-26 | — | — | EP | disclosed |
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | disclosed |
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | disclosed |
| EP-2456754-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | Universite De Strasbourg (FR) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011010013-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011010013-A1 | ACYL GUANIDINE DERIVATIVES MODULATING THE HEDGEHOG PROTEIN SIGNALING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | SHH, GLI1, SMO | SMO 3/4885MAPK14 1421/4885ABCB1 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.