Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | RXRA | P19793 | 4/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195797 | 0.88 | NOTUM (0.53) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL27932708 | 0.85 | NOTUM (0.49) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL13347571 | 0.83 | NOTUM (0.46) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL2188351 | 0.81 | NLRP3 (0.45) | NOTUMKDM4EALDH1A1MAPK1PTPN1 | |
| SCHEMBL5756029 | 0.81 | PTPN1 (0.49) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL15475872 | 0.81 | PTPN1 (0.49) | NOTUMKDM4EALDH1A1MAPK1PTPN1 | |
| SCHEMBL8114245 | 0.81 | NOTUM (0.45) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL28677811 | 0.81 | GRIN1 (0.53) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL13310513 | 0.81 | NOTUM (0.45) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL11337325 | 0.80 | NOTUM (0.63) | NOTUMMAPTKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | claimed |