Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.48 |
| ▸ | MTOR | P42345 | 15/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587015 | 0.87 | PIK3CA (0.52) | PIK3CAMTORPIK3CD | |
| SCHEMBL3601127 | 0.81 | PIK3CA (0.56) | PIK3CAMTORPIK3CD | |
| SCHEMBL3726547 | 0.81 | NPSR1 (0.63) | PIK3CAMTORPIK3CGGAAPIK3CD | |
| SCHEMBL8218959 | 0.81 | PIK3CA (0.59) | PIK3CAMTORPIK3CGATRGAA | |
| SCHEMBL3603774 | 0.80 | PIK3CA (0.55) | PIK3CAMTORPIK3CD | |
| SCHEMBL3597747 | 0.80 | PIK3CA (0.53) | PIK3CAMTORPIK3CD | |
| SCHEMBL2370172 | 0.78 | PIK3CA (0.71) | PIK3CAMTORPIK3CGATRGAA | |
| SCHEMBL3594860 | 0.78 | PIK3CA (0.55) | PIK3CAMTORPIK3CD | |
| SCHEMBL3935094 | 0.78 | PIK3CA (0.49) | PIK3CAMTORPIK3CGATRGAA | |
| SCHEMBL4193910 | 0.78 | GAA (0.48) | PIK3CAMTORPIK3CGATRPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |