Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.42 |
| ▸ | MTOR | P42345 | 6/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217175 | 0.92 | EPHX2 (0.47) | EPHX2PIK3CAMTORPIK3CGEPHX1 | |
| SCHEMBL8213959 | 0.90 | PIK3CA (0.48) | EPHX2PIK3CAMTORPIK3CG | |
| SCHEMBL8217225 | 0.89 | PIK3CA (0.41) | EPHX2PIK3CAMTORPIK3R1PIK3CG | |
| SCHEMBL8214634 | 0.87 | ATR (0.43) | EPHX2PIK3CAMTORATREPHX1 | |
| SCHEMBL8204691 | 0.84 | MTOR (0.45) | PIK3CAMTORPIK3R1PIK3CGATR | |
| SCHEMBL3603774 | 0.81 | PIK3CA (0.55) | PIK3CAMTORPIK3CD | |
| SCHEMBL8212700 | 0.80 | KLKB1 (0.44) | EPHX2PIK3CAMTORPIK3CGATR | |
| SCHEMBL8217162 | 0.78 | KLKB1 (0.47) | EPHX2PIK3CAMTORPIK3CGEPHX1 | |
| SCHEMBL8219738 | 0.78 | EPHX1 (0.42) | EPHX2PIK3CAMTORPIK3CGATR | |
| SCHEMBL8220939 | 0.78 | KLKB1 (0.44) | EPHX2PIK3CAMTOREPHX1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |