Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.53 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16685430 | 1.00 | GSK3B (1.00) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL16685431 | 1.00 | GSK3B (1.00) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL10095181 | 0.86 | MEN1 (0.78) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL6328220 | 0.82 | MAPT (1.00) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL6328218 | 0.82 | MAPT (1.00) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL12821680 | 0.81 | GSK3B (0.81) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL12821679 | 0.81 | GSK3B (0.81) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL8216533 | 0.79 | GSK3B (0.65) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL8216537 | 0.79 | GSK3B (0.65) | GSK3BLMNAMEN1KMT2AMAPT | |
| SCHEMBL10750988 | 0.76 | GSK3B (0.68) | GSK3BLMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | claimed |
| WO-2015065212-A1 | NOVEL N3-AMINOALKYL DERIVATIVES OF 5-ARYLIDENEHYDANTOIN, PHARMACEUTICAL COMPOSITION CONTAINING THE ABOVE AND APPLICATION THEREOF | Uniwersytet Jagielloński (PL) | 2015-05-07 | — | — | WO | disclosed |
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | disclosed |