Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 3/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CCNH | P51946 | 2/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224301 | 0.92 | HCRTR2 (0.47) | HCRTR2HCRTR1SSTR5SPRCCNK | |
| SCHEMBL8224371 | 0.89 | HCRTR2 (0.47) | HCRTR2HCRTR1SSTR5SPRCCNK | |
| SCHEMBL4247674 | 0.87 | HCRTR1 (0.48) | HCRTR2HCRTR1SSTR5SPRRAB9A | |
| SCHEMBL4247680 | 0.87 | HCRTR1 (0.48) | HCRTR2HCRTR1SSTR5SPRRAB9A | |
| SCHEMBL8224358 | 0.86 | SSTR5 (0.43) | HCRTR2HCRTR1SSTR5SPRCCNK | |
| SCHEMBL4250853 | 0.86 | HCRTR2 (0.43) | HCRTR2HCRTR1SSTR5SPRCCNK | |
| SCHEMBL3661341 | 0.86 | HCRTR2 (0.43) | HCRTR2HCRTR1SSTR5SPRCCNK | |
| SCHEMBL4243152 | 0.84 | SSTR5 (0.47) | HCRTR2HCRTR1SSTR5SPRCCNK | |
| SCHEMBL4243155 | 0.84 | SSTR5 (0.47) | HCRTR2HCRTR1SSTR5SPRCCNK | |
| SCHEMBL4239077 | 0.82 | SSTR5 (0.46) | HCRTR2HCRTR1SSTR5SPRCCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897627-B2 | Heteroaryl derivatives as orexin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-7897627-B2 | Heteroaryl derivatives as orexin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| WO-2009080533-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | disclosed |
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR1, HCRTR2, MTNR1A | HCRTR2 2/4885HCRTR1 1/4885SSTR5 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.