Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | FABP3 | P05413 | 3/20 | 0.37 |
| ▸ | FABP4 | P15090 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8218647 | 1.00 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| Hydrochloric Acid SCHEMBL8211300 | 0.90 | PPARA (0.43) | PDE4APDE4BPDE4CPDE4DLMNA | |
| Hydrochloric Acid SCHEMBL8211302 | 0.90 | PPARA (0.43) | PDE4APDE4BPDE4CPDE4DLMNA | |
| Hydrochloric Acid SCHEMBL8216982 | 0.87 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| Hydrochloric Acid SCHEMBL8216986 | 0.87 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| Hydrochloric Acid SCHEMBL8218443 | 0.86 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| Hydrochloric Acid SCHEMBL8218441 | 0.86 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| Hydrochloric Acid SCHEMBL8220690 | 0.85 | NPC1 (0.40) | LMNAKMT2AALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL8220692 | 0.85 | NPC1 (0.40) | LMNAKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL8222329 | 0.85 | ALDH1A1 (0.39) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046218-A | 4,5-DIMETHOXY-2-(3-OXO-3-PHENYL-1-PROPENYL)PYRIDINE USED TO CURE THE DISEASES PRODUCED BY CYTOKINE | SS PHARMACEUTICAL CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0838457-A1 | NOVEL PYRIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS ACTIVE INGREDIENT | SS Pharmaceutical Co., Ltd. (JP) | 1998-04-29 | — | — | EP | disclosed |