Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219412 | 1.00 | MAPT (0.53) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8219415 | 1.00 | MAPT (0.53) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16543012 | 0.84 | NPC1 (0.66) | MAPTMEN1KMT2AALDH1A1IGF1R | |
| SCHEMBL10749179 | 0.79 | MEN1 (0.57) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7690121 | 0.79 | GAA (0.59) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15421542 | 0.79 | MEN1 (0.57) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL10749176 | 0.79 | MEN1 (0.57) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7690119 | 0.79 | GAA (0.59) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11134601 | 0.79 | GSK3B (0.54) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL3467241 | 0.76 | MEN1 (0.72) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | claimed |
| US-8188130-B1 | Anti-cancer hydantoin compounds and methods | UNIVERSITY OF LOUISIANA AT MONROE (US) | 2012-05-29 | — | — | US | disclosed |