Sugi Predict

Sugi Predict / Compounds / SCHEMBL8219756

SCHEMBL8219756

SCHEMBL8219756

CC(C)(C)OC(=O)N[C@@]1(Cc2ccccc2)CCB2CC[C@@H](C(=O)O)N2C1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPIA P62937 2/20 0.42
▸ KMT2A Q03164 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ ACE P12821 1/20 0.38
▸ GRIN2B Q13224 1/20 0.36
▸ CA12 O43570 1/20 0.36
▸ CA1 P00915 1/20 0.36
▸ CA7 P43166 1/20 0.36
▸ CA14 Q9ULX7 1/20 0.36
▸ NAMPT P43490 1/20 0.35
▸ F2 P00734 1/20 0.35
▸ F10 P00742 1/20 0.35
▸ PRSS1 P07477 1/20 0.35
▸ PDE4A P27815 1/20 0.34
▸ PDE4B Q07343 1/20 0.34
▸ PDE4C Q08493 1/20 0.34
▸ PDE4D Q08499 1/20 0.34
▸ AKT1 P31749 3/20 0.34
▸ ATM Q13315 1/20 0.34
▸ NPFFR1 Q9GZQ6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8418697 0.78 PPIA (0.45) PPIAKMT2AL3MBTL1ACECA12
SCHEMBL8224968 0.78 PPIA (0.45) PPIAKMT2AL3MBTL1ACECA12
SCHEMBL8225177 0.76 ELANE (0.35) KMT2AACE
SCHEMBL8225058 0.74 F2 (0.47) PPIAKMT2AL3MBTL1CA12CA1
SCHEMBL8227078 0.74 F2 (0.47) PPIAKMT2AL3MBTL1CA12CA1
SCHEMBL1728442 0.72 PPIA (0.39) PPIAKMT2AL3MBTL1ACEGRIN2B
SCHEMBL27475666 0.72 PPIA (0.52) PPIAKMT2AL3MBTL1CA12CA1
SCHEMBL8087931 0.71 PPIA (0.51) PPIAKMT2AL3MBTL1GRIN2BCA12
SCHEMBL8224965 0.71 PPIA (0.42) PPIAKMT2AL3MBTL1ACEF2
SCHEMBL8224964 0.71 PPIA (0.42) PPIAKMT2AL3MBTL1ACEF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7511039-B2 β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins MYRIAD GENETICS, INC. (US) 2009-03-31 — — US disclosed
US-7511039-B2 β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins MYRIAD GENETICS, INC. (US) 2009-03-31 — — US disclosed
US-20060276408-A1 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins MYRIAD GENETICS, INCORPORATED (US) 2006-12-07 — — US disclosed
US-20060276408-A1 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins MYRIAD GENETICS, INCORPORATED (US) 2006-12-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276408-A1 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins SERPINB1, SERPINE1, SERPINA2 PPIA 732/4885KMT2A 4016/4885L3MBTL1 806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.