Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.53 |
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | PCSK9 | Q8NBP7 | 9/20 | 0.37 |
| ▸ | RPLP1 | P05386 | 3/20 | 0.36 |
| ▸ | RPLP0 | P05388 | 3/20 | 0.36 |
| ▸ | RPS17 | P08708 | 3/20 | 0.36 |
| ▸ | RPSA | P08865 | 3/20 | 0.36 |
| ▸ | RPS2 | P15880 | 3/20 | 0.36 |
| ▸ | RPL35A | P18077 | 3/20 | 0.36 |
| ▸ | RPL7 | P18124 | 3/20 | 0.36 |
| ▸ | RPL17 | P18621 | 3/20 | 0.36 |
| ▸ | RPS4Y1 | P22090 | 3/20 | 0.36 |
| ▸ | RPS3 | P23396 | 3/20 | 0.36 |
| ▸ | RPS12 | P25398 | 3/20 | 0.36 |
| ▸ | RPL13 | P26373 | 3/20 | 0.36 |
| ▸ | RPL10 | P27635 | 3/20 | 0.36 |
| ▸ | RPL12 | P30050 | 3/20 | 0.36 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 3/20 | 0.36 |
| ▸ | RPL22 | P35268 | 3/20 | 0.36 |
| ▸ | RPL4 | P36578 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220391 | 0.85 | JAK2 (0.56) | JAK2JAK3CCNT1CCNKCCNE1 | |
| SCHEMBL8220389 | 0.85 | JAK2 (0.56) | JAK2JAK3CCNT1CCNKCCNE1 | |
| SCHEMBL8219671 | 0.73 | JAK2 (0.53) | JAK2JAK3 | |
| SCHEMBL8219667 | 0.73 | JAK2 (0.53) | JAK2JAK3 | |
| SCHEMBL8224445 | 0.70 | ALOX5AP (0.43) | JAK2JAK3 | |
| SCHEMBL8224443 | 0.70 | ALOX5AP (0.43) | JAK2JAK3 | |
| SCHEMBL6524824 | 0.69 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL6524827 | 0.69 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL12849205 | 0.68 | JAK2 (0.68) | JAK2JAK3CCNT1CCNKCCNE1 | |
| SCHEMBL8219827 | 0.67 | JAK2 (0.58) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475667-A1 | INHIBITORS OF JAK | F. Hoffmann-La Roche AG (CH) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029804-A1 | INHIBITORS OF JAK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-17 | — | — | WO | disclosed |