Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13104192 | 1.00 | F10 (0.46) | F10KLKB1MAPTDYRK1ACLK2 | |
| SCHEMBL12101320 | 0.90 | F10 (0.54) | F10KLKB1DYRK1ACLK2CLK3 | |
| SCHEMBL12892314 | 0.89 | F10 (0.43) | F10DYRK1ACLK2CLK3CFD | |
| SCHEMBL12101392 | 0.89 | F10 (0.43) | F10DYRK1ACLK2CLK3CFD | |
| SCHEMBL8222128 | 0.89 | F10 (0.43) | F10DYRK1ACLK2CLK3CFD | |
| SCHEMBL12101411 | 0.87 | F10 (0.45) | F10KLKB1MAPTCFDNPC1 | |
| SCHEMBL13104199 | 0.83 | F10 (0.47) | F10CFDNPC1RAB9APOLB | |
| SCHEMBL12101351 | 0.83 | F10 (0.47) | F10CFDNPC1RAB9APOLB | |
| SCHEMBL8224894 | 0.83 | F10 (0.44) | F10KLKB1DYRK1ACLK2CLK3 | |
| SCHEMBL13104222 | 0.83 | F10 (0.44) | F10KLKB1DYRK1ACLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051975-B1 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM INT (DE) | 2012-09-12 | — | — | EP | disclosed |
| WO-2007131982-A2 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | WO | disclosed |