Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CFD | P00746 | 9/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12101303 | 0.91 | F10 (0.52) | F10KLKB1CFDAPPBACE1 | |
| SCHEMBL13104352 | 0.89 | F10 (0.42) | F10KLKB1CFD | |
| SCHEMBL8220410 | 0.89 | F10 (0.42) | F10KLKB1CFD | |
| SCHEMBL8220143 | 0.87 | F10 (0.46) | F10KLKB1MAPTCFDPOLB | |
| SCHEMBL13104192 | 0.87 | F10 (0.46) | F10KLKB1MAPTCFDPOLB | |
| SCHEMBL12371503 | 0.81 | F10 (0.41) | F10KLKB1MAPTCFDPOLB | |
| SCHEMBL12101320 | 0.78 | F10 (0.54) | F10KLKB1CFD | |
| SCHEMBL12371502 | 0.77 | F10 (0.41) | F10KLKB1MAPTCFDPOLB | |
| SCHEMBL12101415 | 0.76 | F10 (0.52) | F10KLKB1CFDAPPBACE1 | |
| SCHEMBL12101343 | 0.76 | F10 (0.54) | F10KLKB1CFDRAB9AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051975-B1 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM INT (DE) | 2012-09-12 | — | — | EP | disclosed |