Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16363856 | 0.84 | CTSS (0.45) | CTSSCTSKSYKSERPINE1GAA | |
| SCHEMBL2434610 | 0.84 | CTSS (0.45) | CTSSCTSKSYKSERPINE1GAA | |
| SCHEMBL970153 | 0.83 | CTSS (0.44) | CTSSCTSKSYKPCSK9SERPINE1 | |
| SCHEMBL28763012 | 0.83 | CTSS (0.44) | CTSSCTSKSYKPCSK9SERPINE1 | |
| SCHEMBL25045524 | 0.82 | CTSS (0.46) | CTSSCTSKSYKSERPINE1GAA | |
| SCHEMBL2876608 | 0.81 | CTSS (0.43) | CTSSCTSKSYKPCSK9GAA | |
| SCHEMBL31389109 | 0.81 | CTSS (0.43) | CTSSCTSKSYKPCSK9SERPINE1 | |
| SCHEMBL8068302 | 0.77 | CTSS (0.47) | CTSSCTSKSYKGAAPOLB | |
| SCHEMBL5350831 | 0.76 | MEN1 (0.47) | CTSSCTSKGAAPOLBMALT1 | |
| SCHEMBL22262840 | 0.76 | SYK (0.41) | CTSSCTSKSYKSERPINE1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480545-A1 | FUSED TRIAZOLE AMINES AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011033055-A1 | FUSED TRIAZOLE AMINES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |