Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 14/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220267 | 0.91 | ELANE (0.80) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL8050837 | 0.89 | ELANE (0.79) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL2896569 | 0.89 | ELANE (0.83) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL13540744 | 0.89 | ELANE (0.83) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL8055913 | 0.86 | ELANE (0.65) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL8345574 | 0.85 | ELANE (0.81) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL13412226 | 0.83 | ELANE (0.79) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL8217510 | 0.83 | ELANE (0.79) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL8056317 | 0.83 | ELANE (0.65) | ELANECYP2C9ADRB1HTR1AHRH3 | |
| SCHEMBL13359534 | 0.81 | ELANE (0.56) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030158-A1 | MULTIMERIC HETEROCYCLIC COMPOUNDS USEFUL AS NEUTROPHIL ELASTASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | WO | disclosed |