Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8220267 | 0.92 | ELANE (0.80) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL9914387 | 0.91 | ELANE (0.79) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL2887923 | 0.91 | ELANE (0.79) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL2888564 | 0.91 | ELANE (0.79) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8055913 | 0.90 | ELANE (0.65) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8220635 | 0.90 | ELANE (0.70) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8220629 | 0.89 | ELANE (0.66) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8227499 | 0.89 | ELANE (0.64) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8053053 | 0.89 | ELANE (0.64) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL3482731 | 0.88 | ELANE (1.00) | ELANECYP2C9CYP3A4ADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060206-A1 | 3,4,6,7-TETRAHYDRO-1H-PYRROLO[3,4-D]PYRIMIDINE-2,5-DIONES AND THEIR THERAPEUTIC USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060158-A1 | 4- (4-CYANOPHENYL) -1- (3-TRIFLUOROMETHYLPHENYL) -3,4, 6, 7-TETRAHYDRO-1H-PYRROLO [3, 4- D] PYRIMIDINE-2, 5-DIONE DERIVATIVES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |