Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209325 | 0.79 | LMNA (0.33) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL38665451 | 0.73 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2GRM5LMNA | |
| SCHEMBL30309953 | 0.73 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2GRM5LMNA | |
| SCHEMBL3055736 | 0.71 | GRM5 (0.51) | NPC1RAB9ASMN1; SMN2GRM5LMNA | |
| SCHEMBL25372166 | 0.70 | TDP1 (0.33) | — | |
| SCHEMBL1667886 | 0.69 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL5062777 | 0.69 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL21815833 | 0.68 | APOBEC3A (0.53) | DYRK1ADYRK1BALDH1A1 | |
| SCHEMBL23725063 | 0.66 | AHR (0.32) | KDM4E | |
| SCHEMBL3986841 | 0.66 | MAP4K4 (0.34) | NPC1RAB9ASMN1; SMN2DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008015269-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | disclosed |