SCHEMBL8221933

C=CCOC(=O)NCCC[C@@H]1NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCCC)[C@@H](C)OC(=O)[C@H](CC(=O)c2ccccc2N)NC(=O)[C@H](C(C)CC(=O)O)NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC1=O

nearest known ligand 0.86

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CTSL	P07711	1/20	0.86

▸	DRD1	P21728	1/20	0.86

▸	PTGS1	P23219	1/20	0.86

▸	PDE4A	P27815	1/20	0.86

▸	ITGB3	P05106	2/20	0.38

▸	ITGAV	P06756	2/20	0.38

▸	ALB	P02768	1/20	0.38

▸	EPHA2	P29317	2/20	0.38

▸	F2	P00734	1/20	0.37

▸	PRLHR	P49683	2/20	0.37

▸	TSLP	Q969D9	4/20	0.37

▸	KCNMA1	Q12791	1/20	0.37

▸	KCNMB4	Q86W47	1/20	0.37

▸	F11	P03951	1/20	0.36

▸	KEAP1	Q14145	1/20	0.36

▸	NPR1	P16066	1/20	0.35

▸	NPR3	P17342	1/20	0.35

▸	KRAS	P01116	1/20	0.35

▸	MC4R	P32245	1/20	0.35

▸	MC5R	P33032	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8236195	0.96	CTSL (0.79)	CTSLDRD1PTGS1PDE4AITGB3
SCHEMBL8227349	0.95	CTSL (0.78)	CTSLDRD1PTGS1PDE4AITGB3
SCHEMBL8227383	0.95	CTSL (0.77)	CTSLDRD1PTGS1PDE4AITGB3
SCHEMBL14446427	0.95	CTSL (0.76)	CTSLDRD1PTGS1PDE4AEPHA2
SCHEMBL14446086	0.94	CTSL (0.76)	CTSLDRD1PTGS1PDE4AEPHA2
SCHEMBL8230311	0.94	CTSL (0.96)	CTSLDRD1PTGS1PDE4AITGB3
SCHEMBL14446449	0.93	CTSL (0.74)	CTSLDRD1PTGS1PDE4AITGB3
SCHEMBL14564321	0.93	CTSL (0.91)	CTSLDRD1PTGS1PDE4AITGB3
SCHEMBL8227168	0.93	CTSL (0.74)	CTSLDRD1PTGS1PDE4AEPHA2
Daptomycin SCHEMBL23046993	0.93	CTSL (1.00)	CTSLDRD1PTGS1PDE4AITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20080119395-A1	Novel Depsipeptides and Process for Preparing Same	CUBIST PHARMACEUTICALS, INC.	2008-05-22	—	—	US	disclosed
US-7335726-B2	Lipopeptide stereoisomers, methods for preparing same and useful intermediates	CUBIST PHARMACEUTICALS, INC. (US)	2008-02-26	—	—	US	disclosed
US-7262268-B2	Lipopeptide stereoisomers, methods for preparing same, and useful intermediates	CUBIST PHARMACEUTICALS, INC. (US)	2007-08-28	—	—	US	disclosed
US-20060223983-A1	Lipopeptide stereoisomers, methods for preparing same and useful intermediates	CUBIST PHARMACEUTICALS, INC.	2006-10-05	—	—	US	disclosed
US-20060194714-A1	Novel depsipeptides and process for preparing same	CUBIST PHARMACEUTICALS, INC.	2006-08-31	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20060194714-A1	Novel depsipeptides and process for preparing same	VIP, DNPEP, PREP	CTSL 124/4885DRD1 2758/4885PTGS1 4259/4885
US-20060223983-A1	Lipopeptide stereoisomers, methods for preparing same and useful intermediates	NGLY1, LSS, NRDC	CTSL 187/4885DRD1 3225/4885PTGS1 1577/4885
US-20080119395-A1	Novel Depsipeptides and Process for Preparing Same	VIP, DNPEP, PREP	CTSL 124/4885DRD1 2758/4885PTGS1 4259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.