SCHEMBL8224322

SCHEMBL8224322

CCCC(CCC)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(F)cccc2F)CC1

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 9/20 0.43
CCNA2 P20248 8/20 0.43
CDK1 P06493 5/20 0.43
CCNB1 P14635 5/20 0.43
CCNA1 P78396 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
WNT1 P04628 4/20 0.42
DYRK1A Q13627 4/20 0.42
KDM5A P29375 1/20 0.39
PARP1 P09874 1/20 0.39
CDK14 O94921 1/20 0.37
CCNY Q8ND76 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8224786 0.89 DYRK1A (0.53) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8222417 0.87 L3MBTL1 (0.50) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL953496 0.86 DYRK1A (0.51) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL955461 0.84 DYRK1A (0.54) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL1286745 0.83 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL1286719 0.83 L3MBTL1 (0.48) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL8224789 0.82 L3MBTL1 (0.49) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL955297 0.82 DYRK1A (0.54) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL1286715 0.82 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1
SCHEMBL14143175 0.82 CDK2 (0.46) CDK2CCNA2CDK1CCNB1CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008009954-A1 MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS ASTEX THERAPEUTICS LIMITED (GB) 2008-01-24 WO disclosed
WO-2006077425-A1 COMBINATIONS OF PYRAZOLE KINASE INHIBITORS AND FURTHER ANTITUMOR AGENTS ASTEX THERAPEUTICS LIMITED (GB) 2006-07-27 WO disclosed