Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 12/20 | 0.57 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229746 | 0.88 | CACNA1H (0.61) | CACNA1HHDAC2HDAC1 | |
| SCHEMBL13595932 | 0.84 | CACNA1H (0.81) | CACNA1HNPY5RCYP3A4PAX8 | |
| SCHEMBL8218861 | 0.77 | CACNA1H (0.70) | CACNA1HHDAC2HDAC1 | |
| SCHEMBL8224709 | 0.75 | CACNA1H (0.53) | CACNA1H | |
| SCHEMBL8224751 | 0.75 | CACNA1H (0.84) | CACNA1H | |
| SCHEMBL8217748 | 0.75 | CACNA1H (0.55) | CACNA1HHDAC2HDAC1 | |
| SCHEMBL8218863 | 0.74 | CACNA1H (0.67) | CACNA1H | |
| SCHEMBL8218859 | 0.73 | CACNA1H (1.00) | CACNA1H | |
| SCHEMBL8218935 | 0.72 | CACNA1H (0.89) | CACNA1H | |
| SCHEMBL13595977 | 0.71 | CACNA1H (1.00) | CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033456-A1 | SPIRO-CONDENSED AZETIDINE DERIVATIVES USEFUL IN TREATING PAIN, DIABETES AND DISORDERS OF LIPID METABILISM | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |