Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL8224639 | 0.87 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7368200 | 0.84 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7368204 | 0.79 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL27624819 | 0.76 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| Hydroxyamine SCHEMBL8224643 | 0.74 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8224470 | 0.74 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL8212188 | 0.73 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5702905 | 0.73 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| Hydroxyamine SCHEMBL8212182 | 0.70 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5809534 | 0.69 | MAPK1 (0.61) | PDE4APDE4BPDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057369-A | USE IN THE TREATMENT OF DISEASE STATES ASSOCIATED WITH PROTEINS THAT MEDIATE CELLULAR ACTIVITY WHICH ARE CAPABLE OF BEING MODULATED BY INHIBITING A MATRIX METALLOPROTEINASE (MMP), TUMOR NECROSIS FACTOR (TNF) OR CYCLIC AMP | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 2000-05-02 | — | — | US | claimed |