Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL8212182 | 0.86 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL7368204 | 0.81 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Hydroxyamine SCHEMBL7553741 | 0.80 | MMP9 (0.52) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| Hydroxyamine SCHEMBL8224639 | 0.80 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7207041 | 0.78 | MMP1 (0.61) | PDE4APDE4BPDE4CPDE4DMMP9 | |
| SCHEMBL27624855 | 0.77 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL8212188 | 0.76 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL8224640 | 0.74 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL27624889 | 0.74 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL27624819 | 0.74 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057369-A | USE IN THE TREATMENT OF DISEASE STATES ASSOCIATED WITH PROTEINS THAT MEDIATE CELLULAR ACTIVITY WHICH ARE CAPABLE OF BEING MODULATED BY INHIBITING A MATRIX METALLOPROTEINASE (MMP), TUMOR NECROSIS FACTOR (TNF) OR CYCLIC AMP | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 2000-05-02 | — | — | US | claimed |