Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 3/20 | 0.31 |
| ▸ | PDE1A | P54750 | 2/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401226 | 0.78 | PDE1C (0.33) | PDE1CPDE1APDE1B | |
| SCHEMBL21138800 | 0.61 | ADORA3 (0.34) | — | |
| SCHEMBL21057342 | 0.61 | ADORA3 (0.51) | — | |
| SCHEMBL18099738 | 0.60 | PDE1C (0.46) | PDE1CPDE1APDE1B | |
| SCHEMBL21091174 | 0.58 | PDE1C (0.33) | PDE1CPDE1APDE1B | |
| SCHEMBL13447987 | 0.58 | TNK2 (0.35) | PDE1CPDE1APDE1B | |
| SCHEMBL2324080 | 0.57 | PDE1B (0.53) | PDE1CPDE1APDE1B | |
| SCHEMBL21091193 | 0.55 | PDE1C (0.35) | PDE1CPDE1APDE1B | |
| SCHEMBL17892667 | 0.55 | PDE1C (0.33) | PDE1CPDE1APDE1B | |
| SCHEMBL19264032 | 0.54 | PIK3CA (0.42) | PDE1CPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007106503-A2 | COMBINED TREATMENT WITH AN EGFR KINASE INHIBITOR AND AN AGENT THAT SENSITIZES TUMOR CELLS TO THE EFFECTS OF EGFR KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | WO | disclosed |