Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 2/20 | 0.57 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 9/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24446611 | 0.94 | GRN (0.51) | GRNSORT1LTA4HCPB2MME | |
| SCHEMBL8337764 | 0.83 | GRN (0.46) | GRNSORT1CPB2CTSLCTSB | |
| SCHEMBL19371886 | 0.82 | GRN (0.51) | GRNSORT1LTA4HCPB2MME | |
| SCHEMBL421252 | 0.82 | GRN (0.51) | GRNSORT1LTA4HCPB2MME | |
| SCHEMBL11796335 | 0.82 | GRN (0.51) | GRNSORT1LTA4HCPB2 | |
| SCHEMBL11796323 | 0.82 | GRN (0.51) | GRNSORT1LTA4HCPB2 | |
| SCHEMBL23467369 | 0.81 | GRN (0.50) | GRNSORT1LTA4HCPB2MME | |
| SCHEMBL22312427 | 0.81 | GRN (0.50) | GRNSORT1LTA4HCPB2MME | |
| SCHEMBL25010861 | 0.81 | GRN (0.50) | GRNSORT1LTA4HCPB2MME | |
| SCHEMBL7566961 | 0.81 | GRN (0.50) | GRNSORT1LTA4HCPB2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117557-A2 | DIAMINOPROPANOL RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| WO-2006042150-A1 | DIAMINOALKANE ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |