Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8185415 | 0.86 | EPHX1 (0.44) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL27814902 | 0.83 | EPHX1 (0.43) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL10223956 | 0.83 | EPHX1 (0.43) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL14405811 | 0.81 | KCNH2 (0.46) | KCNN4SIGMAR1KCNH2TMEM97 | |
| SCHEMBL9824390 | 0.81 | EPHX1 (0.45) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL12093362 | 0.80 | KDM4A (0.45) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL2240142 | 0.79 | NOTUM (0.51) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL4374816 | 0.79 | CSNK2A1 (0.47) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL934710 | 0.79 | EPHX1 (0.44) | PGK1EPHX1KDM4AKDM5ANOTUM | |
| SCHEMBL3754799 | 0.79 | EPHX1 (0.44) | PGK1EPHX1KDM4AKDM5ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007079199-A2 | SUBSTITUTED BIS-AMIDE METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, HOLDING, INC. (US) | 2007-07-12 | — | — | WO | disclosed |