Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 9/20 | 0.46 |
| ▸ | AKT2 | P31751 | 8/20 | 0.46 |
| ▸ | AKT1 | P31749 | 7/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8224124 | 0.85 | AKT1 (0.59) | AKT3AKT2AKT1 | |
| SCHEMBL8226975 | 0.84 | AKT1 (0.46) | AKT3AKT2AKT1TEAD1EPHX2 | |
| SCHEMBL8226097 | 0.81 | AKT3 (0.55) | AKT3AKT2AKT1 | |
| SCHEMBL12323938 | 0.81 | AKT3 (0.39) | AKT3AKT2AKT1 | |
| SCHEMBL14302958 | 0.80 | AKT3 (0.46) | AKT3AKT2AKT1 | |
| SCHEMBL14310839 | 0.77 | AKT3 (0.55) | AKT3AKT2AKT1 | |
| SCHEMBL8224129 | 0.77 | AKT3 (0.35) | AKT3AKT2AKT1 | |
| SCHEMBL8223627 | 0.76 | AKT1 (0.54) | AKT3AKT2AKT1EPHX2 | |
| SCHEMBL8224355 | 0.76 | AKT3 (0.40) | AKT3AKT2AKT1 | |
| SCHEMBL8226943 | 0.76 | AKT3 (0.46) | AKT3AKT2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |