Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.46 |
| ▸ | AKT2 | P31751 | 12/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 12/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14304014 | 0.89 | AKT3 (0.54) | AKT1AKT2AKT3 | |
| SCHEMBL8218164 | 0.85 | AKT1 (0.44) | AKT1AKT2AKT3 | |
| SCHEMBL8225912 | 0.84 | AKT3 (0.46) | AKT1AKT2AKT3TEAD1EPHX2 | |
| SCHEMBL14310839 | 0.83 | AKT3 (0.55) | AKT1AKT2AKT3 | |
| SCHEMBL8224355 | 0.78 | AKT3 (0.40) | AKT1AKT2AKT3DPP4 | |
| SCHEMBL8226943 | 0.78 | AKT3 (0.46) | AKT1AKT2AKT3 | |
| SCHEMBL12324605 | 0.78 | AKT3 (0.46) | AKT1AKT2AKT3 | |
| SCHEMBL13958673 | 0.78 | AKT1 (0.43) | AKT1AKT2AKT3TEAD1 | |
| SCHEMBL8226097 | 0.75 | AKT3 (0.55) | AKT1AKT2AKT3 | |
| SCHEMBL8220495 | 0.74 | AKT1 (0.66) | AKT1AKT2AKT3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |