Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.51 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28409650 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL28409647 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL28412550 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL4306013 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL28412286 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL13858798 | 0.85 | ACHE (0.57) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL28412284 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL28409648 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL28551429 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F | |
| SCHEMBL28412287 | 0.85 | ACHE (0.71) | ACHEBCHEFAAHABCC4CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113793-A1 | Process for the Preparation of Highly Pure Donepezil | IND-SWIFT LABORATORIES LIMITED (IN) | 2010-05-06 | — | — | US | disclosed |
| EP-1992616-A1 | Process for the preparation of donepezil and intermediate compounds thereof as well as hydrates of donepezil | Pliva Hrvastka D.O.O. (HR) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007108011-A2 | PROCESS FOR THE PREPARATION OF HIGHLY PURE DONEPEZIL | IND-SWIFT LABORATORIES LIMITED (IN) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007015052-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA ISTRAZIVANJE I RAZVOJ D.O.O. (HR) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113793-A1 | Process for the Preparation of Highly Pure Donepezil | PSEN1, ACHE, PSEN2 | ACHE 2/4885BCHE 5/4885FAAH 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.