Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178921 | 0.85 | SCN5A (0.44) | DYRK1AMETSCN5ATGFBR1NAMPT | |
| SCHEMBL25124479 | 0.74 | DYRK1A (0.41) | DYRK1ASCN5ATGFBR1MAPK14 | |
| SCHEMBL25410704 | 0.72 | NAMPT (0.41) | DYRK1ASCN5ANAMPTSLC5A2AKR1C4 | |
| SCHEMBL25436056 | 0.71 | CYP4F2 (0.44) | DYRK1AMETSCN5ATGFBR1NAMPT | |
| SCHEMBL20193870 | 0.71 | SCN5A (0.39) | DYRK1AMETSCN5ATGFBR1MAPK14 | |
| SCHEMBL21366673 | 0.70 | DYRK1A (0.41) | DYRK1AMETSCN5ATGFBR1MAPK14 | |
| SCHEMBL23128004 | 0.70 | DYRK1A (0.38) | DYRK1AMETSCN5ATGFBR1NAMPT | |
| SCHEMBL25726216 | 0.70 | DYRK1A (0.38) | DYRK1ASCN5ATGFBR1MAPK14TLR9 | |
| SCHEMBL25415202 | 0.69 | DRD2 (0.43) | SLC5A2MGLL | |
| SCHEMBL22388591 | 0.69 | SCN5A (0.40) | DYRK1AMETSCN5ATGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007139860-A2 | HETEROBICYLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |