Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2917638 | 0.75 | GRM5 (0.68) | GRM5ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL2921592 | 0.68 | GRM5 (0.58) | GRM5ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL8227100 | 0.68 | GRM5 (0.44) | GRM5ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL2897935 | 0.67 | SCD (0.44) | GRM5ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL2897938 | 0.67 | SCD (0.44) | GRM5ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL4089356 | 0.67 | GRM5 (0.56) | GRM5ALDH1A1MAPT | |
| SCHEMBL1544945 | 0.65 | KCNH2 (0.45) | GRM5ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL4089560 | 0.64 | GRM5 (0.41) | GRM5ALDH1A1TP53NPC1RAB9A | |
| SCHEMBL4199033 | 0.64 | TP53 (0.51) | ALDH1A1TP53NPC1RAB9AMAPT | |
| SCHEMBL2959556 | 0.64 | GRM5 (1.00) | GRM5ALDH1A1TP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007130820-A2 | MGLUR5 MODULATORS I | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |