Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089560 | 0.77 | GRM5 (0.41) | GRM5ALDH1A1MAPK1KCNH2NPC1 | |
| SCHEMBL2917638 | 0.71 | GRM5 (0.68) | GRM5ALDH1A1MAPK1KCNH2NPC1 | |
| SCHEMBL4097309 | 0.68 | GRM5 (0.64) | GRM5ALDH1A1KCNH2NPC1RAB9A | |
| SCHEMBL4323911 | 0.68 | GRM5 (0.70) | GRM5ALDH1A1MAPK1KCNH2NPC1 | |
| SCHEMBL5054869 | 0.68 | GRM5 (0.70) | GRM5ALDH1A1MAPK1KCNH2NPC1 | |
| SCHEMBL8226908 | 0.68 | GRM5 (0.47) | GRM5ALDH1A1MAPK1KCNH2NPC1 | |
| SCHEMBL1544945 | 0.67 | KCNH2 (0.45) | GRM5ALDH1A1MAPK1KCNH2MEN1 | |
| SCHEMBL4105476 | 0.67 | GRM5 (0.40) | GRM5ALDH1A1MAPK1KCNH2KMT2A | |
| Azd2066 SCHEMBL4331565 | 0.66 | GRM5 (0.72) | GRM5ALDH1A1MAPK1KCNH2MEN1 | |
| Azd2066 SCHEMBL1848325 | 0.66 | GRM5 (0.72) | GRM5ALDH1A1MAPK1KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007130820-A2 | MGLUR5 MODULATORS I | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |